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Sodium Cyanide → 1'-(Phenylmethyl)-(1,4'-bipiperidine)-4'-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Cyanide | HCID 8929 | — |
| 反応物 | 1-Benzyl-4-piperidone | HCID 19220 | — |
| 反応物 | Piperidine, hydrochloride (1:1) | HCID 2723721 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 1'-(Phenylmethyl)-(1,4'-bipiperidine)-4'-carbonitrile | HCID 2733434 | 95.4% |
反応手順
A solution of 5.3 g of sodium cyanide in 20 ml of water is added dropwise at RT to a solution of 18.9 g of 1-benzylpiperid-4-one and 12.16 g of piperidine hydrochloride in 25 ml of MeOH and 25 ml of water and the mixture is stirred for 48 hours at RT. The precipitate formed is wrung, washed with water and dried under vacuum to give 27 g of the expected product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05977359 |
| 出典データセット | uspto-grants-1999_11 |
| ORD ID | ord-cf3867bb03274422b76fa819b273e269 |
| 出典メモ | uspto-grants-1999_11 |