Water → HCID 18394418、化合物

HRID 1602020ノート

反応式

HRID 1602020 の反応式
[NH2:1][C@H:2]([CH2:6][C:7]1[S:8][CH:9]=[CH:10][CH:11]=1)[C:3]([OH:5])=[O:4].[C:12](OC(=O)C)(=[O:14])C.O>C(O)=O>[CH:12]([NH:1][C@H:2]([CH2:6][C:7]1[S:8][CH:9]=[CH:10][CH:11]=1)[C:3]([OH:5])=[O:4])=[O:14]

参加物

5

反応物 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 7111750D-2-Thienylalanine

生成物 1

HCID 18394418HCID 18394418、化合物

試薬・触媒・溶媒 1

HCID 284Formic Acid溶媒

反応条件

温度
0 °C

実験手順

(2R)-2-Amino-3-(2-thienyl)propionic acid (5.00 g, 29.2 mmol) was dissolved in formic acid (50 ml). The solution was cooled to 0° C. Acetic acid anhydride (20 ml) was added dropwise. The reaction mixture was stirred for 16 h, while it was warming up to room temperature. It was cooled to 0° C. Water (20 ml) was added dropwise. The solution was warmed to room temperature. The solvent was removed in vacuo. The residue was suspended in ethyl acetate (20 ml). The precipitation was filtered off, collected, and dried in vacuo, to give 3.60 g of crude (2R)-2-(formylamino)-3-(2-thienyl)propionic acid, which was used for the following step.

後処理

  1. temperaturewas warming up to room temperature
  2. temperatureIt was cooled to 0° C
  3. temperatureThe solution was warmed to room temperature
  4. customThe solvent was removed in vacuo
  5. customThe precipitation
  6. filtrationwas filtered off
  7. customcollected
  8. customdried in vacuo

出典と根拠

ORDレコード
ord-6ddae97f9a9c4b6da03f1514795152bf
出典データセット
uspto-grants-1999_11
特許番号
US05977178

反応ノート

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