Hydrochloric Acid → 5-(Chloromethyl)-3-methylpyrimidine-2,4(1H,3H)-dione
反応式
[CH3:1][N:2]1[C:7](=[O:8])[C:6]([C:9](O)=O)=[CH:5][NH:4][C:3]1=[O:12].[ClH:13]>>[CH3:1][N:2]1[C:7](=[O:8])[C:6]([CH2:9][Cl:13])=[CH:5][NH:4][C:3]1=[O:12]参加物
3
実験手順
3-methyluracil-5-carboxylic acid was treated with HCl and CH2 using standard chloromethylation conditions to give 3-methyl-5-chloromethyl uracil in 52% yield (following standard work-up and recrystallization from ethyl acetate). NMR (DMSO-d6): chemical shifts, peak integrations & D2O exchange experiments diagnostic for structure.
出典と根拠
- ORDレコード
- ord-3b9559282c554c078f8f3c7c7c93dd17
- 出典データセット
- uspto-grants-1999_11
- 特許番号
- US05981467
反応ノート
読み込み中…