Trimethyl orthoformate → 4,4-Dimethoxypiperidine

HRID 1602089ノート

反応式

HRID 1602089 の反応式
O.Cl.[NH:3]1[CH2:8][CH2:7]C(=O)[CH2:5][CH2:4]1.[CH:10](OC)([O:13][CH3:14])[O:11][CH3:12].O.C1(C)C=CC(S(O)(=O)=O)=CC=1>CO>[CH3:12][O:11][C:10]1([O:13][CH3:14])[CH2:7][CH2:8][NH:3][CH2:4][CH2:5]1

参加物

5

反応物 3

HCID 9005Trimethyl orthoformateHCID 521998p-Toluenesulfonic acid monohydrateHCID 2723901Piperonylamine

生成物 1

HCID 5574694,4-Dimethoxypiperidine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Into 9 ml of methanol were dissolved 0.69 g of 4-piperidone hydrochloride monohydrate, 0.74 ml of trimethyl orthoformate and 86 mg of p-toluenesulfonic acid monohydrate, and the reaction was conducted at room temperature for 24 hours. The reaction mixture was evaporated under reduced pressure to remove the solvent. The residue was dissolved into 2 ml of N,N-dimethylacetamide and admixed with 1.4 ml of triethylamine to give a solution of 4,4-dimethoxypiperidine.

後処理

  1. customThe reaction mixture was evaporated under reduced pressure
  2. customto remove the solvent
  3. dissolutionThe residue was dissolved into 2 ml of N,N-dimethylacetamide

出典と根拠

ORDレコード
ord-a9f177263f9d43879d3ff0225fa863ad
出典データセット
uspto-grants-1999_11
特許番号
US05981522

反応ノート

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