関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | (Triphenylphosphoranylidene)acetaldehyde | HCID 75051 | — |
| 反応物 | 5-Methoxy-1H-indole-2-carbaldehyde | HCID 826456 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | (E)-3-(5-methoxy-2-indolyl)-2-propenaldehyde | HCID 19610401 | 26.3% |
反応手順
5-Methoxyindole-2-carboxaldehyde (1.5 g, 8.5 mmol) was dissolved in dry toluene (30 ml) and treated with (formylmethylene)triphenylphosphorane (3 g, 9.8 mmol). The reaction mixture was stirred at 85° C. for 5 h, allowed to cool and chromatographed over silica gel using hexane/EtOAc (7:3). Evaporation of the solvent yielded 0.45 g (26 %) of (E)-3-(5-methoxy-2-indolyl)-2-propenaldehyde, m.p.=145-147° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US05981525 |
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| 出典データセット | uspto-grants-1999_11 |
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| ORD ID | ord-73d513385919411a8ac8170bcc619bbe |
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| 出典メモ | uspto-grants-1999_11 |
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