Cyclopropanecarbonyl chloride → 1,2,3,4-Tetrahydro-1-cyclobutyl-6,7-dimethoxyisoquinoline

反応式

[CH:1]1([CH:4]2[C:13]3[C:8](=[CH:9][C:10]([O:16][CH3:17])=[C:11]([O:14][CH3:15])[CH:12]=3)[CH2:7][CH2:6][NH:5]2)[CH2:3][CH2:2]1.[CH:18]1(C(Cl)=O)CCC1.C1(C(Cl)=O)CC1>>[CH:1]1([CH:4]2[C:13]3[C:8](=[CH:9][C:10]([O:16][CH3:17])=[C:11]([O:14][CH3:15])[CH:12]=3)[CH2:7][CH2:6][NH:5]2)[CH2:3][CH2:2][CH2:18]1

参加物

反応物 3

HCID 77637Cyclopropanecarbonyl chloride

HCID 78705Cyclobutanecarbonyl chloride

HCID 196102151-Cyclopropyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

生成物 1

HCID 196102271,2,3,4-Tetrahydro-1-cyclobutyl-6,7-dimethoxyisoquinoline

実験手順

1,2,3,4-Tetrahydro-1-cyclobutyl-6,7-dimethoxyisoquinoline was prepared by a procedure analogous to that described in example 4 for 1,2,3,4-tetrahydro-1-cyclopropyl-6,7-dimethoxy- isoquinoline but substituting in the first step cyclobutylcarbonyl chloride for cyclopropyl- carbonyl chloride.

出典と根拠

ORDレコード: ord-6e0be7f6516d4e41b581f8bb78719463
出典データセット: uspto-grants-1999_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05981521

反応ノート

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