化工社化工社 化学情報印刷レポート · 研究参考用
Ammonium Chloride → 1-(Quinolin-6-yl)ethan-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonium Chloride | HCID 25517 | — |
| 反応物 | N-Methoxy-N-methylquinoline-6-carboxamide | HCID 55211172 | — |
| 反応物 | HCID 178418689 | HCID 178418689 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 1-(Quinolin-6-yl)ethan-1-one | HCID 258559 | 97.1% |
反応手順
To a solution of quinoline-6-carboxylic acid methoxy-methyl-amide (11.97 g, 55.35 mmol) in anhydrous THF (200 mL) was added MeMgBr (1.5 M in THF, 55 mL, 83 mmol) at 0° C. under nitrogen. The reaction was allowed to warm to ambient temperature over 16 hours. Sat. NH4Cl (20 mL) was added to quench the reaction. The reaction solution was then extracted with EtOAc (3×50 mL). The combined organics were dried over Na2SO4, filtered, and concentrated to give 1-quinolin-6-yl-ethanone (9.2 g, 97% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07732604B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-1b533ba8a3a34f338769c7d82baef3e5 |
| 出典メモ | uspto-grants-2010_06 |