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1-Azabicyclo[2.2.2]oct-3-yl methanesulfonate → HCID 15663665、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Azabicyclo[2.2.2]oct-3-yl methanesulfonate | HCID 416494 | — |
| 反応物 | Sodium | HCID 5360545 | — |
| 反応物 | HCID 178509299 | HCID 178509299 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | HCID 15663665 | HCID 15663665 | — |
反応手順
3-Methanesulphonyloxy-1-azabicylo[2.2.2]octane (D8) (2.0 g, 9.7 mmol) and the sodium salt of 5-aminotetrazole (D15) (2.5 g, 2.0 eq) were dissolved in dry DMF (50 ml) and the reaction carried out as for Example 10. The product (E11) isolated from column chromatography was a white crystalline solid (124 mg, 6.6%), which was recrystallised from ether, m.p. 132-134° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05981545 |
| 出典データセット | uspto-grants-1999_11 |
| ORD ID | ord-de9bc4b61d6341baa4ed99bafa2397b6 |
| 出典メモ | uspto-grants-1999_11 |