Sodium Chloride → HCID 54337658、化合物

HRID 1602386ノート

反応式

HRID 1602386 の反応式
[CH2:1]([O:3][C:4](=[O:22])[CH:5]([CH2:11][C:12]1[C:17]2[CH:18]=[CH:19][O:20][C:16]=2[C:15]([Cl:21])=[CH:14][CH:13]=1)C(OCC)=O)[CH3:2].[Cl-].[Na+]>CS(C)=O.O>[CH2:1]([O:3][C:4](=[O:22])[CH2:5][CH2:11][C:12]1[C:17]2[CH:18]=[CH:19][O:20][C:16]=2[C:15]([Cl:21])=[CH:14][CH:13]=1)[CH3:2]

参加物

5

反応物 2

HCID 5234Sodium ChlorideHCID 53668681HCID 53668681、化合物

生成物 1

HCID 54337658HCID 54337658、化合物収率 66.6%

試薬・触媒・溶媒 2

HCID 679Dimethyl Sulfoxide溶媒HCID 962Water溶媒

実験手順

A mixture of 2-(7-chloro-benzofuran-4-ylmethyl)-malonic acid diethyl ester (2.47 g) and sodium chloride (0.656 g) in DMSO (12 ml) and water (0.5 ml) was heated at 200° for 4 h under nitrogen. The cooled mixture was partitioned between water (80 ml) and ether (3×50 ml) and the combined organic extracts washed with brine (3×50 ml) and dried (MgSO4). The solvent was evaporated to give the title compound as a brown oil (1.28 g)

後処理

  1. temperaturewas heated at 200° for 4 h under nitrogen
  2. customThe cooled mixture was partitioned between water (80 ml) and ether (3×50 ml)
  3. washthe combined organic extracts washed with brine (3×50 ml)
  4. dry with materialdried (MgSO4)
  5. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-21e842bae4194dcc95a76f5d9d3b2d93
出典データセット
uspto-grants-1999_11
特許番号
US05981572

反応ノート

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