Chlorosuccinimide → 3-(5-Chloro-2,3-dihydro-benzofuran-4-yl)propylamine hydrochloride

HRID 1602397ノート

反応式

HRID 1602397 の反応式
[ClH:1].[O:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([CH2:11][CH2:12][CH2:13][NH2:14])[C:5]=2[CH2:4][CH2:3]1.[Cl:15]N1C(=O)CCC1=O>C(O)(=O)C>[ClH:15].[Cl:1][C:9]1[CH:8]=[CH:7][C:6]2[O:2][CH2:3][CH2:4][C:5]=2[C:10]=1[CH2:11][CH2:12][CH2:13][NH2:14]

参加物

4

反応物 2

HCID 31398ChlorosuccinimideHCID 196116703-(2,3-Dihydro-benzofuran-4-yl)-propylamine hydrochloride

生成物 1

HCID 196116663-(5-Chloro-2,3-dihydro-benzofuran-4-yl)propylamine hydrochloride収率 91.3%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A solution of of 3-(2,3-dihydro-benzofuran-4-yl)-propylamine hydrochloride (150 mg) and N-chlorosuccinimide (100 mg) in acetic acid (50 ml) was stirred at room temperature overnight. The solution was evaporated to dryness and the residue taken up in water, basified with 2N sodium hydroxide and extracted with dichloromethane. The extracts were dried and evaporated and the residue disolved in a solution of hydrogen chloride in methanol. Evaporation gave the the title compound (159 mg) as an off-white powder after trituration with ether.

後処理

  1. customThe solution was evaporated to dryness
  2. extractionextracted with dichloromethane
  3. customThe extracts were dried
  4. customevaporated
  5. customEvaporation

出典と根拠

ORDレコード
ord-63f4c3f878b44de49201f7f2c813e6b7
出典データセット
uspto-grants-1999_11
特許番号
US05981572

反応ノート

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