Hydrochloric Acid → HCID 19611685、化合物

HRID 1602403ノート

反応式

HRID 1602403 の反応式
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH2:8][CH2:7][C:6]=2[C:10]=1[CH2:11][CH2:12][CH2:13][NH:14]C(=O)C.[ClH:18]>>[ClH:18].[F:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH2:8][CH2:7][C:6]=2[C:10]=1[CH2:11][CH2:12][CH2:13][NH2:14]

参加物

3

反応物 2

HCID 313Hydrochloric Acid2 回HCID 19611697HCID 19611697、化合物

生成物 1

HCID 19611685HCID 19611685、化合物

実験手順

N-[3-[2,3-Dihydro-5-fluorobenzofuran-4-yl]propyl]acetamide (0.55 g) was heated under reflux in 2M hydrochloric acid (10 ml) for 24 h. The mixture was cooled and washed with dichloromethane, basified with 2M sodium hydroxide and extracted with dichloromethane. Evaporation of the extracts gave an oil which was dissolved in 0.7M methanolic hydrogen chloride (8 ml). Evaporation gave the title compound as a beige solid (0.28 g).

後処理

  1. temperatureThe mixture was cooled
  2. washwashed with dichloromethane
  3. extractionextracted with dichloromethane
  4. customEvaporation of the extracts
  5. customgave an oil which
  6. customEvaporation

出典と根拠

ORDレコード
ord-b48d778870094403815b84d4286d9c35
出典データセット
uspto-grants-1999_11
特許番号
US05981572

反応ノート

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