Hydrochloric Acid → Methanesulfonic acid 2-(2,3-dihydrobenzofuran-4-yl)-ethyl ester
反応式
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[C:9]([CH2:10][CH2:11][OH:12])[C:4]=2[CH2:3][CH2:2]1.C(N(CC)CC)C.[CH3:20][S:21](Cl)(=[O:23])=[O:22].Cl>ClCCl>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[C:9]([CH2:10][CH2:11][O:12][S:21]([CH3:20])(=[O:23])=[O:22])[C:4]=2[CH2:3][CH2:2]1参加物
6
実験手順
A solution of 2-(2,3-dihydrobenzofuran-4-yl)-ethanol (1.13 g) in dichloromethane (11 ml) was treated with triethylamine (1.25 ml), followed by methanesulfonyl chloride (0.64 ml). After 5 min the reaction mixture was poured into 2M hydrochloric acid (10 ml) and extracted with dichloromethane (2×10 ml). The combined extracts were washed with water (10 ml), dried (Na2SO4) and the solvent evaporated to give the title compound (1.76 g) as a yellow oil.
後処理
- extractionextracted with dichloromethane (2×10 ml)
- washThe combined extracts were washed with water (10 ml)
- dry with materialdried (Na2SO4)
- customthe solvent evaporated
出典と根拠
- ORDレコード
- ord-564546274a1a4379ae83c396ab8078cc
- 出典データセット
- uspto-grants-1999_11
- 特許番号
- US05981572
反応ノート
読み込み中…