Sodium Cyanide → 4-(2-Cyanoethyl)-2,3-dihydro-benzofuran
反応式
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[C:9]([CH2:10][CH2:11]OS(C)(=O)=O)[C:4]=2[CH2:3][CH2:2]1.[C-:17]#[N:18].[Na+]>CS(C)=O.O>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[C:9]([CH2:10][CH2:11][C:17]#[N:18])[C:4]=2[CH2:3][CH2:2]1参加物
5
実験手順
A solution of methanesulfonic acid 2-(2,3-dihydrobenzofuran-4-yl)-ethyl ester (1.71 g) in dimethylsulfoxide (14 ml) was treated with sodium cyanide (381 mg) and heated at 80° for 1 h. The suspension was cooled to 20°, diluted with water (14 ml) and extracted with ethyl acetate (2×17 ml). The combined extracts were washed with 5% aqueous sodium chloride (17 ml), dried (Na2SO4) and the solvent evaporated to give the title compound (1.22 g) as a brown oil which crystallised on standing.
後処理
- temperatureheated at 80° for 1 h
- temperatureThe suspension was cooled to 20°
- extractionextracted with ethyl acetate (2×17 ml)
- washThe combined extracts were washed with 5% aqueous sodium chloride (17 ml)
- dry with materialdried (Na2SO4)
- customthe solvent evaporated
出典と根拠
- ORDレコード
- ord-686ec95f76354d50ba0b25e48b288069
- 出典データセット
- uspto-grants-1999_11
- 特許番号
- US05981572
反応ノート
読み込み中…