Triethylamine → HCID 53753153、化合物

HRID 1602426ノート

反応式

HRID 1602426 の反応式
Cl.[F:2][C:3]1[CH:4]=[CH:5][C:6]2[O:10][CH2:9][CH2:8][C:7]=2[C:11]=1[CH2:12][CH2:13][CH2:14][NH2:15].C(N(CC)CC)C.[CH:23]1([C:26](Cl)=[O:27])[CH2:25][CH2:24]1>ClCCl>[F:2][C:3]1[CH:4]=[CH:5][C:6]2[O:10][CH2:9][CH2:8][C:7]=2[C:11]=1[CH2:12][CH2:13][CH2:14][NH:15][C:26]([CH:23]1[CH2:25][CH2:24]1)=[O:27]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 77637Cyclopropanecarbonyl chlorideHCID 19611685HCID 19611685、化合物

生成物 1

HCID 53753153HCID 53753153、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

3-(2,3-Dihydro-5-fluorobenzofuran-4-yl)propylamine hydrochloride (0.27 g) in dichloromethane (5 ml) containing triethylamine (0.5 ml) was cooled in ice. Cyclopropanecarbonyl chloride (0.12 ml) was added and stirring continued at 5° for 2 h and at room temperature for 16 h. The mixture was washed with water and passed through a solid phase extraction cartridge using ethyl acetate/hexane (1:1) to give the title compound as a white solid (0.21 g).

後処理

  1. temperaturewas cooled in ice
  2. washThe mixture was washed with water
  3. extractionpassed through a solid phase extraction cartridge

出典と根拠

ORDレコード
ord-3733681783fb482e829aeda36ea603c5
出典データセット
uspto-grants-1999_11
特許番号
US05981572

反応ノート

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