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Water → 2-Methyl-1-[4-(methylthio)phenyl]-1-butanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Thioanisole | HCID 7520 | — |
| 反応物 | Butanoyl chloride, 2-methyl- | HCID 93697 | — |
| 反応物 | Aluminum(III) Chloride | HCID 6451240 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 2-Methyl-1-[4-(methylthio)phenyl]-1-butanone | HCID 15480643 | — |
反応手順
To a suspension of AlCl3 (35.4 g) in CHCl3 (500 mL) at -10° C. was added dropwise 2-methylbutyryl chloride (31.3 g) followed by thioanisole (31.2 mL). The mixture was then stirred at r.t. for 20 min. and was then cooled back to 0° C. Water (200 mL) was then added over 30 min. The CHCl3 layer was separated and dried over MgSO4. After filtration and removal of the solvent, the residue was dried under vacuum at 80° C. for 2 h to give 35 g of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05981576 |
| 出典データセット | uspto-grants-1999_11 |
| ORD ID | ord-368aaa041f5f4ba889def7dee84b6ca7 |
| 出典メモ | uspto-grants-1999_11 |