Methyl formate → Nalpha-formyl-DL-methionine amide

HRID 1602756ノート

反応式

HRID 1602756 の反応式
[NH2:1][CH:2]([C:7]([NH2:9])=[O:8])[CH2:3][CH2:4][S:5][CH3:6].[CH:10](OC)=[O:11]>>[CH:10]([NH:1][CH:2]([C:7]([NH2:9])=[O:8])[CH2:3][CH2:4][S:5][CH3:6])=[O:11]

参加物

3

反応物 2

HCID 7865Methyl formateHCID 5687422-Amino-4-(methylthio)butanamide

生成物 1

HCID 18329562Nalpha-formyl-DL-methionine amide収率 55%

実験手順

30 g (0.20 mole) DL-methionine amide were agitated with 250 ml methyl formate for two days at room temperature, during which fine, slightly yellow crystals developed. They were filtered off and recrystallized out of a mixture of 150 ml hexane and 160 ml ethanol. After cooling off, filtering, washing and drying, 23 g (55%) Nα -formyl-DL-methionine amide were obtained in the form of colorless crystals with a melting point of 121-122° C.

後処理

  1. filtrationThey were filtered off
  2. customrecrystallized out of a mixture of 150 ml hexane and 160 ml ethanol
  3. temperatureAfter cooling off
  4. filtrationfiltering
  5. washwashing
  6. customdrying

出典と根拠

ORDレコード
ord-2bfbf8db1e2b4e1da89df3c38f14a767
出典データセット
uspto-grants-1999_11
特許番号
US05985632

反応ノート

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