Aniline → Diethyl 2-butyl-3-(phenylamino)-2-butenedioate
反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:8]([CH:12]([C:18](=O)[C:19]([O:21][CH2:22][CH3:23])=[O:20])[C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH2:9][CH2:10][CH3:11]>>[CH2:8]([C:12](=[C:18]([NH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[C:19]([O:21][CH2:22][CH3:23])=[O:20])[C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH2:9][CH2:10][CH3:11]参加物
3
反応条件
- 温度
- 75 °C
実験手順
A mixture of 1 g of aniline with 2.65 g of the product of Step A and 150 mg of SiliporiteRNK10 was stirred for 3 days at 75° C. and then the reaction mixture was cooled down and chromatographed on silica (eluant: hexane-ethyl acetate (9-1) to obtain 1.55 g of the expected product.
後処理
- temperaturethe reaction mixture was cooled down
- customchromatographed on silica (eluant