Water → Timolol Maleate

HRID 1603402

反応式

HRID 1603402 の反応式
[CH3:1][CH2:2][CH:3]([C:5]([OH:7])=[O:6])C.[CH3:8][C:9]([NH:12][CH2:13][C@H:14]([OH:28])[CH2:15][O:16][C:17]1[C:18]([N:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)=[N:19][S:20][N:21]=1)([CH3:11])[CH3:10].[OH2:29]>C([O-])(=O)C.[Zn+2].C([O-])(=O)C>[CH3:11][C:9]([NH:12][CH2:13][C@H:14]([OH:28])[CH2:15][O:16][C:17]1[C:18]([N:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)=[N:19][S:20][N:21]=1)([CH3:8])[CH3:10].[CH:3](/[C:5]([OH:7])=[O:6])=[CH:2]/[C:1]([OH:16])=[O:29]

参加物

5

反応物 3

HCID 962Water2 回HCID 83142-Methylbutanoic AcidHCID 33624Timolol

生成物 1

HCID 5281056Timolol Maleate

試薬・触媒・溶媒 1

HCID 11192Zinc Acetate触媒

実験手順

15 grams of Carbopol 974P is dispersed in 40 grams of heavy mineral oil USP and is added to 841.5 grams of water containing 2.5 grams of timolol meleate with vigorous stirring. 100 grams of water containing 1.0 gram of zinc acetate is added in a controlled fashion with homogenization to get a particle size distribution size below 5 micron.

後処理

  1. customto get a particle size distribution size below 5 micron

出典と根拠

ORDレコード
ord-9cca235f36404870a5655411ed51d3e0
出典データセット
uspto-grants-1999_11
特許番号
US05989535

関連ノート

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