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tert-butyl N-(4-aminobutyl)carbamate → 1-(4-N-Boc-aminobutyl)-1H-pyrrole-2,5-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | tert-butyl N-(4-aminobutyl)carbamate | HCID 4351 | — |
| 反応物 | Maleic Anhydride | HCID 7923 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 1-(4-N-Boc-aminobutyl)-1H-pyrrole-2,5-dione | HCID 59709139 | — |
反応手順
To a solution of N-BOC-1,4-diaminobutane (8.324 g, 0.044 mol) in dry toluene (50 ml) was added maleic anhydride (4.336 g, 0.044 mol) and the solution heated at reflux under Dean-Stark conditions for two days. The solvent was removed and the residue purified by silica column chromatography eluting with 25-40% ethyl acetate in hexane to give the title compound, 1.461 g, 12%, as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07736635B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-5f8e5d07e27c4cbb8e72a0fb83256796 |
| 出典メモ | uspto-grants-2010_06 |