化工社化工社 化学情報印刷レポート · 研究参考用
5-Methoxy-6-(trifluoromethyl)indoline → 5-Methoxy-6-trifluoromethyl-1-[4-(pyridin-4-ylthiomethyl)phenyl Carbamoyl]indoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Methoxy-6-(trifluoromethyl)indoline | HCID 11206713 | — |
| 反応物 | Benzenamine, 4-[(4-pyridinylthio)methyl]- | HCID 18005148 | — |
| 反応物 | Phenylcarbamate | HCID 21896570 | — |
| 生成物 | 5-Methoxy-6-trifluoromethyl-1-[4-(pyridin-4-ylthiomethyl)phenyl Carbamoyl]indoline | HCID 18005150 | 64% |
反応手順
4-(Pyridin-4-ylthiomethyl)aniline (0.37 g, 1.71 mmol) was converted to the phenylcarbamate and treated with 5-methoxy-6-trifluoromethylindoline (D111) (0.37 g, 1.71 mmol) as in the method of Example 26 to give the title compound (0.5 g, 64%) as a white crystalline solid m.p. 174-5° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05990133 |
| 出典データセット | uspto-grants-1999_11 |
| ORD ID | ord-9d08a06f7a7546d8b42c091e0a6c4797 |
| 出典メモ | uspto-grants-1999_11 |