2,3-Dimethoxybenzaldehyde → 1-(2,3-Dimethoxyphenyl)ethanol
反応式
[CH3:1][O:2][C:3]1[C:10]([O:11][CH3:12])=[CH:9][CH:8]=[CH:7][C:4]=1[CH:5]=[O:6].[CH3:13][Mg]Br>C(OCC)C>[CH3:1][O:2][C:3]1[C:10]([O:11][CH3:12])=[CH:9][CH:8]=[CH:7][C:4]=1[CH:5]([OH:6])[CH3:13]参加物
4
反応条件
- 温度
- 0 °C
実験手順
A solution of 2,3-dimethoxybenzaldehyde (10.0 g, 60.2 mmol) in dry ethyl ether (100 ml) was added at 0° C. with a 3M solution of methylmagnesium bromide in ethyl ether (35 ml) and left under stirring at 0° C. for 0.5 h. Afterwards the reaction mixture was added with a diphasic mixture of ethyl ether and an ammonium chloride saturated solution, extracting the aqueous phase with ethyl ether. The organic extracts were dried and the solvent was evaporated off under reduced pressure, thereby obtaining 10.06 g of the title compound (92% yield).
後処理
- waitleft
- extractionan ammonium chloride saturated solution, extracting the aqueous phase with ethyl ether
- customThe organic extracts were dried
- customthe solvent was evaporated off under reduced pressure
出典と根拠
- ORDレコード
- ord-a717c936a7ac49008a804e86032e9f27
- 出典データセット
- uspto-grants-1999_11
- 特許番号
- US05990142
反応ノート
読み込み中…