2-Bromoethanol → (R)-1-Methyl-1,2,3,4-tetrahydroisoquinoline

HRID 1604030ノート

反応式

HRID 1604030 の反応式
[CH3:1][C@@H:2]([NH2:9])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.Br[CH2:11][CH2:12]O>ClCCl>[CH3:1][C@@H:2]1[C:3]2[C:8](=[CH:7][CH:6]=[CH:5][CH:4]=2)[CH2:12][CH2:11][NH:9]1

参加物

4

反応物 2

HCID 108982-BromoethanolHCID 6431891-Phenethylamine, (+)-

生成物 1

HCID 11084033(R)-1-Methyl-1,2,3,4-tetrahydroisoquinoline収率 85,303.602%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
51 °C

実験手順

51.45 g(0.43 mmole) of (R)-(+)-α-methylbenzylamine was dissolved in 52 ml of dichloromethane and 63.78 g(0.51 mmole) of 2-bromoethanol was added thereto. This mixture was stirred at 51° C. for 50 hours to complete the reaction. The reaction solution was concentrated under reduced pressure and the residue was subjected to fractional distillation to obtain 54 g of the title compound having pale yellow color.

後処理

  1. customthe reaction
  2. concentrationThe reaction solution was concentrated under reduced pressure
  3. distillationthe residue was subjected to fractional distillation

出典と根拠

ORDレコード
ord-df70338bc03e4c9dbabd52dcb029ba68
出典データセット
uspto-grants-1999_11
特許番号
US05990311

反応ノート

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