Toluene → (N-n-Butylcarbamoyl)methyltriphenylphosphonium Chloride

HRID 1604468ノート

反応式

HRID 1604468 の反応式
[C:1]1([P:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C([CH:24]([Cl:28])[C:25]([NH2:27])=[O:26])CCC.[C:29]1([CH3:35])[CH:34]=[CH:33]C=CC=1>>[Cl-:28].[CH2:33]([NH:27][C:25]([CH2:24][P+:7]([C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)=[O:26])[CH2:34][CH2:29][CH3:35]

参加物

4

反応物 3

HCID 1140TolueneHCID 11776TriphenylphosphineHCID 573063372-Chlorohexanamide

生成物 1

HCID 19603925(N-n-Butylcarbamoyl)methyltriphenylphosphonium Chloride収率 89.1%

実験手順

A solution of triphenyl phosphine (26.23 g, 0.1 mol) and n-butyl chloroacetamide (14.96 g, 0.1 mol) in toluene (250 mL) was refluxed with stirring for 22 h. After cooling to room temperature, the mixture was filtered and dried under high vacuum to afford 36.72 g (89.1% yield) of the title compound as white crystals. This material was used without further purification.

後処理

  1. filtrationthe mixture was filtered
  2. customdried under high vacuum

出典と根拠

ORDレコード
ord-83fb0f28c8c84517b1b7d7cc335a14b7
出典データセット
uspto-grants-1999_11
特許番号
US05994396

反応ノート

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