Triethylamine → 2,6-Dichloro-1-methylsulfonyloxymethyl-3-(methoxymethoxy)benzene

HRID 1604536ノート

反応式

HRID 1604536 の反応式
[Cl:1][C:2]1[C:9]([O:10][CH2:11][O:12][CH3:13])=[CH:8][CH:7]=[C:6]([Cl:14])[C:3]=1[CH2:4][OH:5].C(N(CC)CC)C.[CH3:22][S:23](Cl)(=[O:25])=[O:24]>ClCCl>[Cl:14][C:6]1[CH:7]=[CH:8][C:9]([O:10][CH2:11][O:12][CH3:13])=[C:2]([Cl:1])[C:3]=1[CH2:4][O:5][S:23]([CH3:22])(=[O:25])=[O:24]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 536407392,6-Dichloro-3-(methoxymethoxy)benzyl alcohol

生成物 1

HCID 196032302,6-Dichloro-1-methylsulfonyloxymethyl-3-(methoxymethoxy)benzene

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

To a solution of 2,6-dichloro-3-(methoxymethoxy)benzyl alcohol (1.1 g) and triethylamine (563 mg) in dichloromethane was added a solution of methanesulfonyl chloride (585 mg) in dichloromethane at <20° C. over 5 minutes under nitrogen atmosphere, and the mixture was stirred at the same temperature for 30 minutes and under ice-cooling for 30 minutes. The reaction mixture was washed with saturated sodium bicarbonate solution and brine, dried over magnesium sulfate and evaporated in vacuo to give 1,3-dichloro-2-methanesulfonyloxymethyl-4-(methoxymethoxy)benzene.

後処理

  1. temperaturecooling for 30 minutes
  2. washThe reaction mixture was washed with saturated sodium bicarbonate solution and brine
  3. dry with materialdried over magnesium sulfate
  4. customevaporated in vacuo

出典と根拠

ORDレコード
ord-136e26488a2d4c9cbb0a13c1f20ad7fb
出典データセット
uspto-grants-1999_11
特許番号
US05994368

反応ノート

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