Potassium Carbonate → Methyl 6-hydroxymethyl-3-methylquinoline-2-carboxylate

HRID 1604548ノート

反応式

HRID 1604548 の反応式
C([O:4][CH2:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[N:12]=[C:11]([C:16]([O:18][CH2:19]C)=[O:17])[C:10]([CH3:21])=[CH:9]2)(=O)C.C(=O)([O-])[O-].[K+].[K+]>CO>[OH:4][CH2:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[N:12]=[C:11]([C:16]([O:18][CH3:19])=[O:17])[C:10]([CH3:21])=[CH:9]2

参加物

4

反応物 2

HCID 11430Potassium CarbonateHCID 19603481Ethyl 6-acetoxymethyl-3-methylquinoline-2-carboxylate

生成物 1

HCID 19603207Methyl 6-hydroxymethyl-3-methylquinoline-2-carboxylate収率 5.9%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of ethyl 6-acetoxymethyl-3-methylquinoline-2-carboxylate (420 mg) and potassium carbonate in methanol was stirred for 30 minutes under ice-cooling. After filtration the filtrate was concentrated and partitioned between ethyl acetate and water. The organic layer was washed with water, dried over magnesium sulfate and concentrated to give methyl 6-hydroxymethyl-3-methylquinoline-2-carboxylate (20 mg).

後処理

  1. temperaturecooling
  2. filtrationAfter filtration the filtrate
  3. concentrationwas concentrated
  4. custompartitioned between ethyl acetate and water
  5. washThe organic layer was washed with water
  6. dry with materialdried over magnesium sulfate
  7. concentrationconcentrated

出典と根拠

ORDレコード
ord-88db145c2b284e7a8be0441b53a3e69c
出典データセット
uspto-grants-1999_11
特許番号
US05994368

反応ノート

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