Hydrochloric Acid → 8-(2,6-Dichloro-3-hydroxybenzyloxy)-2-methylquinoline

HRID 1604562ノート

反応式

HRID 1604562 の反応式
[Cl:1][C:2]1[C:20]([O:21]COC)=[CH:19][CH:18]=[C:17]([Cl:25])[C:3]=1[CH2:4][O:5][C:6]1[CH:7]=[CH:8][CH:9]=[C:10]2[C:15]=1[N:14]=[C:13]([CH3:16])[CH:12]=[CH:11]2.Cl>CO>[Cl:1][C:2]1[C:20]([OH:21])=[CH:19][CH:18]=[C:17]([Cl:25])[C:3]=1[CH2:4][O:5][C:6]1[CH:7]=[CH:8][CH:9]=[C:10]2[C:15]=1[N:14]=[C:13]([CH3:16])[CH:12]=[CH:11]2

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 196033098-[2,6-Dichloro-3-(methoxymethoxy)benzyloxy]-2-methylquinoline

生成物 1

HCID 196033608-(2,6-Dichloro-3-hydroxybenzyloxy)-2-methylquinoline収率 52.9%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 8-[2,6-dichloro-3-(methoxymethoxy)benzyloxy]-2-methylquinoline (1.57 g) in methanol was dropwise added conc. hydrochloric acid (2.7 ml) at 0° C., and the mixture was stirred for 5 minutes. The solvent was removed, and water was added thereto. The mixture was neutralized with saturated sodium bicarbonate solution, and the resulting participates were collected by filtration to give 8-(2,6-dichloro-3-hydroxybenzyloxy)-2-methylquinoline (734 mg) as a solid.

後処理

  1. customat 0° C.
  2. customThe solvent was removed
  3. additionwater was added
  4. filtrationthe resulting participates were collected by filtration

出典と根拠

ORDレコード
ord-bee8461d7e4f4fbe85b6b04ff8ec518e
出典データセット
uspto-grants-1999_11
特許番号
US05994368

反応ノート

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