Sulfuric Acid → HCID 19603840、化合物

HRID 1604628ノート

反応式

HRID 1604628 の反応式
[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([N+:19]([O-:21])=[O:20])=[C:13]([CH2:15][C:16]([OH:18])=[O:17])[CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(=O)(=O)(O)O.[CH:27](O)([CH3:29])[CH3:28]>>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([N+:19]([O-:21])=[O:20])=[C:13]([CH2:15][C:16]([O:18][CH:27]([CH3:29])[CH3:28])=[O:17])[CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 3

HCID 1118Sulfuric AcidHCID 3776IsopropanolHCID 19603791HCID 19603791、化合物

生成物 1

HCID 19603840HCID 19603840、化合物

実験手順

A mixture of 5-benzyloxy-2-nitrophenylacetic acid (4.0 g) and conc. sulphuric acid (0.6 ml) in isopropyl alcohol (40 ml) was stirred under reflux for 1 day. After removal of solvent by evaporation, the resulting residue was dissolved with ethyl acetate. The ethyl acetate extract was washed successively with aqueous sodium hydrogen carbonate solution, water, and brine, and was dried over magnesium sulfate, and concentrated under reduced pressure to give isopropyl 5-benzyloxy-2-nitrophenylacetate (4.20 g).

後処理

  1. temperatureunder reflux for 1 day
  2. customAfter removal of solvent
  3. customby evaporation
  4. dissolutionthe resulting residue was dissolved with ethyl acetate
  5. extractionThe ethyl acetate extract
  6. washwas washed successively with aqueous sodium hydrogen carbonate solution, water, and brine
  7. dry with materialwas dried over magnesium sulfate
  8. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-caa0200444f44ff19a4f554d46e8c6f1
出典データセット
uspto-grants-1999_11
特許番号
US05994378

反応ノート

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