Hydrochloric Acid → 2-Piperidinecarboxamide, 1-butyl-N-(2,6-dimethylphenyl)-, hydrochloride (1:1), (2S)-
反応式
[CH3:1][CH2:2][CH2:3][CH2:4][N:5]1[C@H:10]([C:11]([NH:13][C:14]2[C:15]([CH3:21])=[CH:16][CH:17]=[CH:18][C:19]=2[CH3:20])=[O:12])[CH2:9][CH2:8][CH2:7][CH2:6]1.C([C@H]([C@@H](C([O-])=O)O)O)([O-])=O.[ClH:32]>C(O)(C)C>[CH3:1][CH2:2][CH2:3][CH2:4][N:5]1[C@H:10]([C:11]([NH:13][C:14]2[C:15]([CH3:21])=[CH:16][CH:17]=[CH:18][C:19]=2[CH3:20])=[O:12])[CH2:9][CH2:8][CH2:7][CH2:6]1.[ClH:32]参加物
4
反応条件
- 温度
- 50 °C
実験手順
Levobupivacaine (S,S)-tartrate (50 g, 0.069 mol) was suspended in isopropanol (150 ml) and heated to 50° C. Hydrogen chloride (5 g, 0.14 mol) gas was introduced. The temperature rose to 65° C. and the solids dissolved. The mixture was heated to 80° C. to ensure complete dissolution. The mixture was cooled to 5° C. and a solid crystallised. The solid was filtered off and washed with isopropanol (2×50 ml) and dried in vacuo to give levobupivacaine hydrochloride (21.9 g, 40%).