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Acetaldehyde → 9-Benzoyl-8-bromo-1,2,3,4-tetrahydrocarbazole-3-carboxylic acid

HRID 1605099
ノート
印刷プレビュー

反応式

HRID 1605099 の反応式
[C:1]([N:9]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[Br:19])N=CC)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.BrC1C=CC=CC=1NN=CC.[CH2:31]1[CH:37]([C:38]([OH:40])=[O:39])[CH2:36][CH2:35][C:33](=O)[CH2:32]1.C(=O)C.Cl>O.C(O)(=O)C>[C:1]([N:9]1[C:33]2[CH2:32][CH2:31][CH:37]([C:38]([OH:40])=[O:39])[CH2:36][C:35]=2[C:18]2[C:13]1=[C:14]([Br:19])[CH:15]=[CH:16][CH:17]=2)(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

8

反応物 5

HCID 177AcetaldehydeHCID 313Hydrochloric AcidHCID 1927304-Oxocyclohexanecarboxylic acidHCID 68139504Acetaldehyde 1-benzoyl-1-(2-bromophenyl)hydrazoneHCID 86733215Acetaldehyde 2-bromophenyl hydrazone

生成物 1

HCID 215486279-Benzoyl-8-bromo-1,2,3,4-tetrahydrocarbazole-3-carboxylic acid

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒2 回HCID 962Water溶媒

実験手順

A solution of acetaldehyde 1-benzoyl-1-(2-bromophenyl)hydrazone, prepared from 11 g. of acetaldehyde 2-bromophenyl hydrazone (see below), and 9.16 g. of cyclohexanone-4-carboxylic acid in 25 ml. glacial acetic acid was heated on a hot plate until evolution of acetaldehyde was no longer detected (about two hours), 25 ml. glacial acetic acid saturated with hydrogen chloride was added and heating was continued for 30 minutes. The mixture was cooled and cautiously diluted with water, and the resulting solid was collected by filtration and washed with water to give 2.24 g. of the title compound; m.p. 196°-198°C. (chloroform-heptane).

後処理

  1. custom(about two hours), 25 ml
  2. temperatureheating
  3. temperatureThe mixture was cooled
  4. filtrationthe resulting solid was collected by filtration
  5. washwashed with water
  6. customto give 2.24 g

出典と根拠

ORDレコード
ord-f6ccce52625749f6b08db8e5fc5078c1
出典データセット
uspto-grants-1976_04
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US03948939

反応ノート

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