Water → 7-Methylthio-3,7-dimethyloctan-1-al

HRID 1605142ノート

反応式

HRID 1605142 の反応式
[CH3:1][S:2][C:3]([CH3:13])([CH3:12])[CH2:4][CH2:5][CH2:6][CH:7]([CH3:11])[CH2:8][CH2:9][OH:10].C(N(CC)CC)C.O.CCCCCC>CS(C)=O>[CH3:1][S:2][C:3]([CH3:12])([CH3:13])[CH2:4][CH2:5][CH2:6][CH:7]([CH3:11])[CH2:8][CH:9]=[O:10]

参加物

6

反応物 4

HCID 962WaterHCID 8058HexaneHCID 8471TriethylamineHCID 215493537-Methylthio-3,7-dimethyloctan-1-ol

生成物 1

HCID 215493787-Methylthio-3,7-dimethyloctan-1-al

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒2 回

実験手順

To 2.04 g. (10 mmol.) of 7-methylthio-3,7-dimethyloctan-1-ol in 25 ml. of freshly distilled dimethylsulfoxide, under nitrogen at 20°, is added via syringe 11.2 ml. (80 mmol.) of triethylamine while stirring vigorously. Sulfur trioxide-2 pyridine complex (10.28 g., 64 mmol.) in dimethylsulfoxide (50 ml.) is added slowly to the mixture via dropping funnel under the same conditions. After addition is complete, the reaction mixture is stirred for 5 minutes and poured into cold water. Hexane is added and the organic layer separated, washed well with water and dried over calcium sulfate. Evaporation of the solvent at reduced pressure affords 7-methylthio-3,7-dimethyloctan-1-al.

後処理

  1. additionAfter addition
  2. customthe organic layer separated
  3. washwashed well with water
  4. dry with materialdried over calcium sulfate
  5. customEvaporation of the solvent at reduced pressure

出典と根拠

ORDレコード
ord-79856178340d4dd8a22f1a10de38eaed
出典データセット
uspto-grants-1976_04
特許番号
US03948996

反応ノート

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