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3-Methoxyphenol → 1,3-Dimethyl-4-(m-methoxyphenyloxy)-benzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Methoxyphenol | HCID 9007 | — |
| 反応物 | Tetramethylurea | HCID 12437 | — |
| 反応物 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 反応物 | Benzene, 1-bromo-2,4-dimethyl- | HCID 68503 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 1,3-Dimethyl-4-(m-methoxyphenyloxy)-benzene | HCID 21549657 | — |
反応手順
A mixture of 1,3-dimethyl-4-bromobenzene, 10.5 g. of m-methoxyphenol, 4.65 g. of cuprous oxide, 40 ml. of tetramethylurea, and 75 ml. of N-methylpyrrolidone is stirred at 165° for 96 hours. The resultant mixture is diluted with water and extracted with methylene chloride. The methylene chloride extracts are chromatographed on 300 g. of alumina with gradient elution using hexane:ether to give 1,3-dimethyl-4-(m-methoxyphenyloxy)-benzene.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03949084 |
| 出典データセット | uspto-grants-1976_04 |
| ORD ID | ord-6b639ce2671f4045b8a7ddbf95e838ee |
| 出典メモ | uspto-grants-1976_04 |