Dichloromethane → HCID 68137584、化合物

HRID 1605189ノート

反応式

HRID 1605189 の反応式
[CH3:1][C:2]1([O:8][C:9]([NH:11][C@H:12]([C:20]([OH:22])=[O:21])[CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[O:10])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.Cl.[CH3:24][O:25][C:26](=[O:30])[C@H:27]([CH3:29])[NH2:28].C(Cl)Cl>C(N(CC)CC)C>[CH3:1][C:2]1([O:8][C:9]([NH:11][C@H:12]([C:20]([OH:22])=[O:21])[CH2:13][C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)=[O:10])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]1.[CH3:24][O:25][C:26](=[O:30])[C@H:27]([CH3:29])[NH2:28]

参加物

5

反応物 3

HCID 6344DichloromethaneHCID 2733257Alanine methyl ester hydrochlorideHCID 54520100HCID 54520100、化合物

生成物 1

HCID 68137584HCID 68137584、化合物

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

実験手順

A solution of 0.67 mM of the hydroxysuccinimide ester of N-(1-methylcyclohexyloxycarbonyl) phenylalanine and 0.70 mM of alanine methyl ester hydrochloride in 10 ml. of methylene chloride is treated with triethylamine until the pH is adjusted to 7.6-8.0. Reaction is stirred six hours and the reaction mixture is washed according to the following procedure: one time with dilute sodium bicarbonate solution; once with 50% saturated sodium chloride solution; once with 0.2 N sulfuric acid saturated with sodium sulfate; and two times with 50% saturated sodium chloride solution. The resulting material is dried over sodium sulfate and the washing procedure repeated. The solvent is removed in vacuo to afford N-(1-methylcyclohexyloxycarbonyl) phenylalanine-alanine methyl ester.

後処理

  1. customReaction
  2. washthe reaction mixture is washed
  3. dry with materialThe resulting material is dried over sodium sulfate
  4. customThe solvent is removed in vacuo

出典と根拠

ORDレコード
ord-cdb3420a54b247efaf2fc0f4e2d209a3
出典データセット
uspto-grants-1976_04
特許番号
US03948971

反応ノート

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