Water → HCID 21546967、化合物

To 5 ml. of a solution prepared by mixing one part of water and 9 parts of glacial acetic acid, and then cooling to 0°-10° C., is added 300 mg. of 1-hydroxy-3-cyclopentene-1-carbonitrile. To this is then added 5 ml. of a solution prepared by saturating glacial acetic acid with gaseous hydrogen bromide and cooling to 0°-10° C. The resulting mixture is allowed to stand at room temperature overnight. It is then evaporated to dryness in vacuo, and the residue is partitioned between ethyl acetate and 5% sodium bicarbonate solution. The ethyl acetate layer is separated, and then dried using anhydrous magnesium sulfate. Removal of the ethyl acetate by evaporation in vacuo affords 1-hydroxy-3-cyclopentene-1-carboxamide.

1. customof a solution prepared
2. temperaturecooling to 0°-10° C.
3. additionis added 300 mg
4. additionTo this is then added 5 ml
5. customof a solution prepared
6. concentrationby saturating glacial acetic acid with gaseous hydrogen bromide
7. temperaturecooling to 0°-10° C
8. customIt is then evaporated to dryness in vacuo
9. customthe residue is partitioned between ethyl acetate and 5% sodium bicarbonate solution
10. customThe ethyl acetate layer is separated
11. customdried
12. customRemoval of the ethyl acetate
13. customby evaporation in vacuo

ORDレコード

ord-447c3f7bdc3e4f36b5affc3e5cb92540

出典データセット

uspto-grants-1976_04

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US03950390