3-Ethylphenol → (4-Ethyl-2-hydroxyphenyl)(4-fluorophenyl)methanone

反応式

[CH2:1]([C:3]1[CH:4]=[C:5]([OH:9])[CH:6]=[CH:7][CH:8]=1)[CH3:2].[F:10][C:11]1[CH:19]=[CH:18][C:14]([C:15](Cl)=[O:16])=[CH:13][CH:12]=1>>[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([C:15]([C:14]2[CH:18]=[CH:19][C:11]([F:10])=[CH:12][CH:13]=2)=[O:16])=[C:5]([OH:9])[CH:4]=1)[CH3:2]

参加物

反応物 2

HCID 121013-Ethylphenol

HCID 678794-Fluorobenzoyl chloride

生成物 1

HCID 12562657(4-Ethyl-2-hydroxyphenyl)(4-fluorophenyl)methanone収率 5.3%

実験手順

3-Ethylphenol (24.4g) and 4-fluorobenzoyl chloride (34.9g) were reacted together as in Example 11 giving three main fractions: B (11.4g) 126°-129°C at 0.07 mmHg; C (7.9g), 129°-132°C at 0.06 mmHg; D (5.9g), 132°-150°C at 0.06 mmHg, all containing ~80% of the required isomer. B (4.0g) was separated by preparative thin layer chromatography to give the title compound (2.6g), m.p. 44°-48°C.

後処理

customB (11.4g) 126°-129°C
customC (7.9g), 129°-132°C
customD (5.9g), 132°-150°C
customB (4.0g) was separated by preparative thin layer chromatography

出典と根拠

ORDレコード: ord-37bfe15f09714ba685a5c03749ea8082
出典データセット: uspto-grants-1976_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US03951999

反応ノート

読み込み中…

参加物