HCID 86733267、化合物 → N-Acetyl-DL-phenylglycine

HRID 1606259

反応式

HRID 1606259 の反応式
[C:1]([NH:4][C:5](C1SC=CC=1)([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1C)[C:6]([OH:8])=[O:7])(=[O:3])[CH3:2]>[Ni].CC(C)=O>[C:1]([NH:4][CH:5]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:6]([OH:8])=[O:7])(=[O:3])[CH3:2]

参加物

4

反応物 1

HCID 86733267HCID 86733267、化合物

生成物 1

HCID 85935N-Acetyl-DL-phenylglycine収率 73%

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 180Acetone溶媒

実験手順

Two (2.0) cc of Raney nickel (WII) was suspended in 15 ml of acetone, and refluxed for 7 minutes. Cooling the suspension to room temperature, 315 mg of α-acetylamino-α-tolylthiophenylacetic acid was added, followed by 5.5 hours' stirring at room temperature. The insoluble matter was separated by filtration, and washed with ethanol. The filtrate and washing were combined and concentrated under reduced pressure. The residue was crystallized from an ether-n-hexane system. Thus 141 mg of α-acetylaminophenylacetic acid was obtained. The yield was 73%.

後処理

  1. temperaturerefluxed for 7 minutes
  2. customThe insoluble matter was separated by filtration
  3. washwashed with ethanol
  4. washThe filtrate and washing
  5. concentrationconcentrated under reduced pressure
  6. customThe residue was crystallized from an ether-n-hexane system

出典と根拠

ORDレコード
ord-386f7d6536084da18b1ad9a9baae91ff
出典データセット
uspto-grants-1976_04
特許番号
US03952044

関連ノート

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