4-Butylamino-6-chloro-2-methyl-5-nitronicotinic acid ethyl ester → HCID 178448823、化合物
反応式
[CH2:1]([O:3][C:4]([C:6]1[C:7]([CH3:21])=[N:8][C:9](Cl)=[C:10]([N+:17]([O-:19])=[O:18])[C:11]=1[NH:12][CH2:13][CH2:14][CH2:15][CH3:16])=[O:5])[CH3:2].O.[S-2:23].[Na+].[Na+]>O>[CH2:13]([NH:12][C:11]1[C:10]([N+:17]([O-:19])=[O:18])=[C:9]([SH:23])[N:8]=[C:7]([CH3:21])[C:6]=1[C:4]([O:3][CH2:1][CH3:2])=[O:5])[CH2:14][CH2:15][CH3:16]参加物
4
実験手順
31.5 g. of 4-butylamino-6-chloro-2-methyl-5-nitropyridine-3-carboxylic acid ethyl ester (0.1 Mol.) are dissolved in 100 ml. of alcohol. 14.8 g. of sodium sulfide monohydrate and about 2 ml. of water are added and the mixture is stirred for one hour without cooling. The precipitated 4-butylamino-6-mercapto-2-methyl-5-nitropyridine-3-carboxylic acid, ethyl ester is filtered off, yield 27.5 g. (88%), m.p. 140°-142° (ethanol).