Furfurylamine → HCID 21543990、化合物

HRID 1606599ノート

反応式

HRID 1606599 の反応式
Cl[C:2]1[CH:10]=[C:9]([Cl:11])[C:8]([S:12]([CH3:15])(=[O:14])=[O:13])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[CH2:16]([NH2:22])[C:17]1[O:21][CH:20]=[CH:19][CH:18]=1>Cl>[CH2:16]([NH:22][C:2]1[CH:10]=[C:9]([Cl:11])[C:8]([S:12]([CH3:15])(=[O:14])=[O:13])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5])[C:17]1[O:21][CH:20]=[CH:19][CH:18]=1

参加物

4

反応物 2

HCID 3438FurfurylamineHCID 221013652,4-Dichloro-5-methanesulfonylbenzoic acid

生成物 1

HCID 21543990HCID 21543990、化合物

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

反応条件

温度
125 °C

実験手順

A mixture of 2,4-dichloro-5-methylsulfonylbenzoic acid (15 g.; 0.055 mole) and furfurylamine (30 ml.) is heated in an oil bath at 125° C. under an atmosphere of nitrogen for 3 hours then poured into cold, dilute hydrochloric acid (200 ml.) to precipitate 17.6 g., (98%) of 2-furfurylamino-4-chloro-5-methylsulfonylbenzoic acid, m.p. 204° C. (dec.) after recrystallization from nitromethane (200 ml.).

後処理

  1. customto precipitate 17.6 g
  2. custom, (98%) of 2-furfurylamino-4-chloro-5-methylsulfonylbenzoic acid, m.p. 204° C. (dec.) after recrystallization from nitromethane (200 ml.)

出典と根拠

ORDレコード
ord-637cf091076449e4a4797afe651be93f
出典データセット
uspto-grants-1976_04
特許番号
US03953476

反応ノート

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