Salicylic Acid → HCID 13066647、化合物

反応式

[NH2:1][C:2]1[CH:11]=[CH:10][C:9]([NH2:12])=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].[C:13]([OH:22])(=O)[C:14]1[C:15](=[CH:17][CH:18]=[CH:19][CH:20]=1)[OH:16].P(Cl)(Cl)Cl>>[C:13]([NH:1][C:2]1[CH:11]=[CH:10][C:9]([NH:12][C:13](=[O:22])[C:14]2[C:15](=[CH:17][CH:18]=[CH:19][CH:20]=2)[OH:16])=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5])(=[O:22])[C:14]1[C:15](=[CH:17][CH:18]=[CH:19][CH:20]=1)[OH:16]

参加物

反応物 3

HCID 338Salicylic Acid

HCID 24387Phosphorus trichloride

HCID 13066644Methyl 2,5-diaminobenzoate

生成物 1

HCID 13066647HCID 13066647、化合物収率 54%

実験手順

By the procedure similar to that described in Example 15, methyl 2,5-diaminobenzoate was condensed with salicylic acid with the aid of phosphorus trichloride to obtain methyl 2,5-bis(salicylamido)-benzoate (Yield; 54%). The product was confirmed to be identical to that obtained in Example 4.

出典と根拠

ORDレコード: ord-e23dc1342bde4dbe9bd5e6441c9d07b1
出典データセット: uspto-grants-1976_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US03953496

反応ノート

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