Carbon Disulfide → 1-Isothiocyanato-1,2,3,4-tetrahydronaphthalene

HRID 1606704

反応式

HRID 1606704 の反応式
[CH:1]1([NH2:11])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1.C(N(CC)CC)C.[C:19](=S)=[S:20].C1(N=C=NC2CCCCC2)CCCCC1>C(OCC)(=O)C>[CH:1]1([N:11]=[C:19]=[S:20])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1

参加物

6

反応物 4

HCID 6348Carbon DisulfideHCID 8471TriethylamineHCID 10868DicyclohexylcarbodiimideHCID 180661,2,3,4-Tetrahydro-1-naphthylamine

生成物 1

HCID 213934781-Isothiocyanato-1,2,3,4-tetrahydronaphthalene

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

To a stirred solution of 0.01 mole of 1,2,3,4-tetrahydro-1-naphthylamine in ethyl acetate is added 0.01 mole of triethylamine and 0.011 mole of carbon disulfide. The mixture is stirred about one hour and then 0.01 mole of dicyclohexyl carbodiimide is added. The mixture is stirred overnight, and the mixture filtered to remove solid dicyclohexylthiourea. The filtrate is evaporated, and the residue is purified by dry column chromatography to give 1,2,3,4-tetrahydro-1-naphthyl isothiocyanate.

後処理

  1. stirringThe mixture is stirred overnight
  2. filtrationthe mixture filtered
  3. customto remove solid dicyclohexylthiourea
  4. customThe filtrate is evaporated
  5. customthe residue is purified
  6. customby dry column chromatography

出典と根拠

ORDレコード
ord-9333fce444804ddba252135245397d90
出典データセット
uspto-grants-1976_04
特許番号
US03953506

関連ノート

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