Sodium Chloride → 4-Benzoyl-2,3-dihydro-1H-inden-1-one

HRID 1606718ノート

反応式

HRID 1606718 の反応式
[C:1]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH2:15][CH2:16][C:17]([OH:19])=O)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl-].[Al+3].[Cl-].[Cl-].[Cl-].[Na+]>O>[C:1]([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:10]=1[CH2:15][CH2:16][C:17]2=[O:19])(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 5234Sodium ChlorideHCID 6451240Aluminum(III) ChlorideHCID 12286997Benzenepropanoic acid, 2-benzoyl-

生成物 1

HCID 131930944-Benzoyl-2,3-dihydro-1H-inden-1-one

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
160 °C

実験手順

Five g. of o-benzoyl-β-phenylpropionic acid, 13 g. of anhydrous aluminum chloride and 1.3 g. of sodium chloride are admixed together and heated at 160°C for 1 hour. After cooling, water is added to the mixture, followed by extraction with chloroform. The extract is washed with a 5 % aqueous solution of sodium bicarbonate and water in that order and, then, dried. The solvent is distilled off under reduced pressure and the residue is dissolved in ethanol. The solution is decolorized with activated carbon and recrystallized from ethanol. The procedure yields 4-benzoylindan-1-one as crystals melting at 86°-88°C.

後処理

  1. temperatureAfter cooling
  2. extractionfollowed by extraction with chloroform
  3. washThe extract is washed with a 5 % aqueous solution of sodium bicarbonate and water in that order
  4. customdried
  5. distillationThe solvent is distilled off under reduced pressure
  6. dissolutionthe residue is dissolved in ethanol
  7. customrecrystallized from ethanol

出典と根拠

ORDレコード
ord-3e617f3e9cc742f38adf3420db637316
出典データセット
uspto-grants-1976_04
特許番号
US03953500

反応ノート

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