Water → Ethyl (4Z)-8-oxo-4-octenoate

HRID 1606746ノート

反応式

HRID 1606746 の反応式
[OH:1][CH:2]1[CH2:9][CH2:8][CH:7]=[CH:6][CH2:5][CH2:4][C:3]1=[O:10].[CH2:11](O)[CH3:12].C1C=CC=CC=1.C([O-])(=[O:22])C.C([O-])(=O)C.C([O-])(=O)C.C([O-])(=O)C.[Pb+4].O>CCOCC>[O:10]=[CH:3][CH2:4][CH2:5]/[CH:6]=[CH:7]\[CH2:8][CH2:9][C:2]([O:1][CH2:11][CH3:12])=[O:22]

参加物

6

反応物 4

HCID 962WaterHCID 2737052-Hydroxy-5-cycloocten-1-oneHCID 21965192Npc112006HCID 178418268HCID 178418268、化合物

生成物 1

HCID 24972431Ethyl (4Z)-8-oxo-4-octenoate

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

To 220 mg. of 2-hydroxy-5-cycloocten-1-one in 5 ml. of 30% ethanol/benzene is added 860 mg. of 85% lead tetraacetate in portions. After about 3 hours at room temperature, water and ether are added to the reaction mixture. The aqueous phase is extracted several times with ether. The combined ether extracts are washed with 2M sodium carbonate and saturated sodium chloride solution, dried over calcium sulfate and evaporated to give ethyl (4Z)-8-oxo-4-octenoate in high purity.

後処理

  1. extractionThe aqueous phase is extracted several times with ether
  2. washThe combined ether extracts are washed with 2M sodium carbonate and saturated sodium chloride solution
  3. dry with materialdried over calcium sulfate
  4. customevaporated

出典と根拠

ORDレコード
ord-81ffe967e75e47acae41219b6ba9acde
出典データセット
uspto-grants-1976_04
特許番号
US03953532

反応ノート

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