Phenyl glycidyl ether → 1-Phenoxy-2-propanol

HRID 1606792

反応式

HRID 1606792 の反応式
CC(C1C(O)=CC=CC=1O)=O.[C:12]1([O:18][CH2:19][CH:20]2[O:22][CH2:21]2)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[OH-].C([N+](C)(C)C)C1C=CC=CC=1>C(OCCO)C>[OH:22][CH:20]([CH2:19][O:18][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH3:21]

参加物

5

反応物 3

HCID 31217Phenyl glycidyl etherHCID 66854Benzyltrimethylammonium hydroxideHCID 696872',6'-Dihydroxyacetophenone

生成物 1

HCID 928391-Phenoxy-2-propanol

試薬・触媒・溶媒 1

HCID 8076Glycol monoethyl ether溶媒

実験手順

A solution of 2,6-dihydroxyacetophenone (15.2g.), phenylglycidyl ether (15.0 g) and benzyltrimethylammonium hydroxide (5 drops of a 40% solution) in 2-ethoxyethanol (75 ml) was heated under reflux for 48 hours. The solvent was removed under reduced pressure and the resulting solid was washed with ether. Recrystallization from aqueous ethanol gave 1-(2-acetyl-3-hydroxyphenoxy(-2-hydroxy-3-phenoxypropane, 19.0 g, as pale lemon needles, m.p. 100.5°-101.5° C.

後処理

  1. temperatureunder reflux for 48 hours
  2. customThe solvent was removed under reduced pressure
  3. washthe resulting solid was washed with ether
  4. customRecrystallization from aqueous ethanol

出典と根拠

ORDレコード
ord-4c190907babd413c942a9bdef2d33127
出典データセット
uspto-grants-1976_04
特許番号
US03953604

関連ノート

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