2-(beta-Hydroxyethyl)amino-6-(beta-hydroxyethyl)amino-4-chloronitrobenzene → 2-(beta-Hydroxyethyl)amino-6-(beta-hydroxyethyl)amino-4-(beta-aminoethyl)aminonitrobenzene

HRID 1606858ノート

反応式

HRID 1606858 の反応式
[OH:1][CH2:2][CH2:3][NH:4][C:5]1[CH:10]=[C:9](Cl)[CH:8]=[C:7]([NH:12][CH2:13][CH2:14][OH:15])[C:6]=1[N+:16]([O-:18])=[O:17]>C(N)CN>[OH:1][CH2:2][CH2:3][NH:4][C:5]1[CH:10]=[C:9]([NH:4][CH2:5][CH2:6][NH2:16])[CH:8]=[C:7]([NH:12][CH2:13][CH2:14][OH:15])[C:6]=1[N+:16]([O-:18])=[O:17]

参加物

3

反応物 1

HCID 200710912-(beta-Hydroxyethyl)amino-6-(beta-hydroxyethyl)amino-4-chloronitrobenzene

生成物 1

HCID 198511702-(beta-Hydroxyethyl)amino-6-(beta-hydroxyethyl)amino-4-(beta-aminoethyl)aminonitrobenzene

試薬・触媒・溶媒 1

HCID 3301Ethylenediamine溶媒

実験手順

0.13 mole (36.5 g) of 2-(β-hydroxyethyl)amino-6-(β-hydroxyethyl)amino-4-chloronitrobenzene, whose synthesis was described in stage 1 of example 2, was heated for 2 hours at 130° C. in 150 ml of ethylenediamine, then the reaction medium diluted with 450 ml of ice water to precipitate out the desired product. After filtering and water washing to neutrality, the product obtained was dried under vacuum in the presence of P2O5. It was recrystallized from 96° ethanol and melted at 220° C.

後処理

  1. customthe reaction
  2. customto precipitate out the desired product
  3. filtrationAfter filtering
  4. customwater washing to neutrality, the product obtained
  5. dry with materialwas dried under vacuum in the presence of P2O5
  6. customIt was recrystallized from 96° ethanol and melted at 220° C.

出典と根拠

ORDレコード
ord-a1373ab1801340939b767731612b3c47
出典データセット
uspto-grants-1989_09
特許番号
US04863482

反応ノート

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