O-((2E)-3-Chloro-2-propen-1-yl)hydroxylamine → HCID 178458082、化合物

HRID 1606865ノート

反応式

HRID 1606865 の反応式
[CH3:1][N:2]1[CH:6]=[C:5]([CH:7]2[CH2:12][C:11](=[O:13])[CH:10]([C:14](=O)[CH2:15][CH3:16])[C:9](=[O:18])[CH2:8]2)[CH:4]=[N:3]1.[Cl:19]/[CH:20]=[CH:21]/[CH2:22][O:23][NH2:24]>>[Cl:19][CH:20]=[CH:21][CH2:22][O:23]/[N:24]=[C:14](/[CH:10]1[C:11](=[O:13])[CH2:12][CH:7]([C:5]2[CH:4]=[N:3][N:2]([CH3:1])[CH:6]=2)[CH2:8][C:9]1=[O:18])\[CH2:15][CH3:16]

参加物

3

反応物 2

HCID 158058O-((2E)-3-Chloro-2-propen-1-yl)hydroxylamineHCID 145764915-(1-methyl-1H-pyrazol-4-yl)-2-propionylcyclohexane-1,3-dione

生成物 1

HCID 178458082HCID 178458082、化合物

実験手順

To 200 ml of an ethanolic solution of 20.0 g (81 mmols) of 5-(1-methyl-1H-pyrazol-4-yl)-2-propionylcyclohexane-1,3-dione was added 210 ml (84 mmols) of 0.4 mol ethanolic solution of (E)-3-chloro-2-propenyloxyamine. The mixture was reacted for 8 hours with stirring. After completion of the reaction, the reaction mixture was concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography (ethyl acetate) to give 12.5 g of the product.

後処理

  1. customThe mixture was reacted for 8 hours
  2. customAfter completion of the reaction
  3. concentrationthe reaction mixture was concentrated under reduced pressure
  4. customThe resulting crude product was purified by silica gel column chromatography (ethyl acetate)

出典と根拠

ORDレコード
ord-bda6b4cfbc5f4d8b80bad58e57b74e72
出典データセット
uspto-grants-1989_09
特許番号
US04863504

反応ノート

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