O-((2E)-3-Chloro-2-propen-1-yl)hydroxylamine → 2-[(E)-N-(3-chloroprop-2-enoxy)-C-ethylcarbonimidoyl]-5-(2-methylpyrazol-3-yl)cyclohexane-1,3-dione

HRID 1606866ノート

反応式

HRID 1606866 の反応式
[CH3:1][N:2]1[C:6]([CH:7]2[CH2:12][C:11](=[O:13])[CH:10]([C:14](=O)[CH2:15][CH3:16])[C:9](=[O:18])[CH2:8]2)=[CH:5][CH:4]=[N:3]1.[Cl:19]/[CH:20]=[CH:21]/[CH2:22][O:23][NH2:24]>>[Cl:19][CH:20]=[CH:21][CH2:22][O:23]/[N:24]=[C:14](/[CH:10]1[C:11](=[O:13])[CH2:12][CH:7]([C:6]2[N:2]([CH3:1])[N:3]=[CH:4][CH:5]=2)[CH2:8][C:9]1=[O:18])\[CH2:15][CH3:16]

参加物

3

反応物 2

HCID 158058O-((2E)-3-Chloro-2-propen-1-yl)hydroxylamineHCID 145362755-(1-methyl-1H-pyrazol-5-yl)-2-propionylcyclohexane-1,3-dione

生成物 1

HCID 1415602412-[(E)-N-(3-chloroprop-2-enoxy)-C-ethylcarbonimidoyl]-5-(2-methylpyrazol-3-yl)cyclohexane-1,3-dione

実験手順

To 5 ml of an ethanolic solution of 0.35 g (1.4 mmols) of 5-(1-methyl-1H-pyrazol-5-yl)-2-propionylcyclohexane-1,3-dione was added 3.8 ml (1.4 mmols) of 0.38 mol ethanolic solution of (E)-3-chloro-2-propenyloxyamine. The mixture was reacted for 10 hours with stirring. After completion of the reaction, the reaction mixture was concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography (hexane:ethyl acetate=b 1:2) to give 0.25 g of the product.

後処理

  1. customThe mixture was reacted for 10 hours
  2. customAfter completion of the reaction
  3. concentrationthe reaction mixture was concentrated under reduced pressure
  4. customThe resulting crude product was purified by silica gel column chromatography (hexane:ethyl acetate=b 1:2)

出典と根拠

ORDレコード
ord-5531e9712f6d42a1ab5f13ad87a3c89a
出典データセット
uspto-grants-1989_09
特許番号
US04863504

反応ノート

読み込み中…