ethyl 2-((E)-4-methoxybenzylidene)butyrate → HCID 14329809、化合物

HRID 1606935ノート

反応式

HRID 1606935 の反応式
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH3:7][O:8][C:9]1[CH:23]=[CH:22][C:12](/[CH:13]=[C:14](\[CH2:20][CH3:21])/[C:15](OCC)=[O:16])=[CH:11][CH:10]=1>CCOCC>[CH3:7][O:8][C:9]1[CH:23]=[CH:22][C:12](/[CH:13]=[C:14](\[CH2:20][CH3:21])/[CH2:15][OH:16])=[CH:11][CH:10]=1

参加物

4

反応物 2

HCID 10933410ethyl 2-((E)-4-methoxybenzylidene)butyrateHCID 21226445Aluminium lithium hydride2 回

生成物 1

HCID 14329809HCID 14329809、化合物収率 83.4%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒3 回

実験手順

To a suspension of lithium aluminum hydride (3 g) in dry ether (300 ml) was added a solution of ethyl 2-((E)-4-methoxybenzylidene)butyrate (19 g) in dry ether (30 ml) at 0° C. with stirring. The mixture was stirred at the same temperature for 3 hours and excess lithium aluminum hydride was decomposed with wet ether. The reaction mixture was filtered and the filtrate was washed with water, dried over magnesium sulfate and then evaporated to dryness to give 2-((E)-4-methoxybenzylidene)butan-1-ol (13 g).

後処理

  1. stirringThe mixture was stirred at the same temperature for 3 hours
  2. filtrationThe reaction mixture was filtered
  3. washthe filtrate was washed with water
  4. dry with materialdried over magnesium sulfate
  5. customevaporated to dryness

出典と根拠

ORDレコード
ord-c2d69bba2595479286dc2ecef9a89370
出典データセット
uspto-grants-1989_09
特許番号
US04863926

反応ノート

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