Acetic Acid → (E)-4-ethyl-2-methoxyimino-5-nitro-3-hexenamide

HRID 1606939ノート

反応式

HRID 1606939 の反応式
[CH2:1](/[C:3](/[CH:11]([N+:13]([O-:15])=[O:14])[CH3:12])=[CH:4]\[C:5](=[N:9][OH:10])[C:6]([NH2:8])=[O:7])[CH3:2].[N+](=[CH2:18])=[N-].C(O)(=O)C>CO>[CH2:1](/[C:3](/[CH:11]([N+:13]([O-:15])=[O:14])[CH3:12])=[CH:4]\[C:5](=[N:9][O:10][CH3:18])[C:6]([NH2:8])=[O:7])[CH3:2]

参加物

5

反応物 3

HCID 176Acetic AcidHCID 9550DiazomethaneHCID 86742405(E)-4-ethyl-2-hydroxyimino-5-nitro-3-hexenamide

生成物 1

HCID 86742404(E)-4-ethyl-2-methoxyimino-5-nitro-3-hexenamide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To (E)-4-ethyl-2-hydroxyimino-5-nitro-3-hexenamide (37 mg) in methanol (5 ml) was added excess etheral diazomethane at -20° C. The resulting mixture was allowed to stand at 0° C. for an hour and then acetic acid was added thereto until the yellow color of the solution was discharged. The resulting reaction mixture was evaporated under reduced pressure to give an oil which was purified by preparative thin layer chromatography, developing with chloroform containing 5% methanol to give (E)-4-ethyl-2-methoxyimino-5-nitro-3-hexenamide (21.5 mg).

後処理

  1. waitto stand at 0° C. for an hour
  2. customThe resulting reaction mixture
  3. customwas evaporated under reduced pressure
  4. customto give an oil which
  5. customwas purified by preparative thin layer chromatography

出典と根拠

ORDレコード
ord-04395c6aa7d7415380eb349b5531032f
出典データセット
uspto-grants-1989_09
特許番号
US04863926

反応ノート

読み込み中…