化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Iodide → 2-Iodo-4-(trifluoromethyl)phenol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Iodide | HCID 5238 | — |
| 反応物 | 4-(Trifluoromethyl)phenol | HCID 67874 | — |
| 溶媒 | Hydrochloric Acid | HCID 313 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-Iodo-4-(trifluoromethyl)phenol | HCID 11572816 | 91.5% |
反応手順
4-(trifluoromethyl)-phenol (8 g) in anhydrous DMF (80 ml) was cooled to 0° C. NaI (9.06 g) and chloroamine-T (16.1 g) was added portionwise and stirred at room temperature overnight. Then diluted with 2M HCl and extracted with ethylacetate. The organic phase was washed with sodium thiosulfate solution, dried (MgSO4) and concentrated in vacuo. The residue was purified by chromatography (silica, eluting with isohexane:ethyl acetate) to give the sub-title compound as a yellow oil (13 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07737135B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-1e2552f608414f098ff5e79320e33a6d |
| 出典メモ | uspto-grants-2010_06 |