Trimethyl orthoacetate → HCID 178495861、化合物

HRID 1607085ノート

反応式

HRID 1607085 の反応式
[NH2:1][C:2]1[N:7]=[C:6]([OH:8])[CH:5]=[CH:4][CH:3]=1.[CH3:9][O:10][C:11](OC)(OC)[CH3:12]>>[CH3:9][O:10][C:11](=[N:1][C:2]1[N:7]=[C:6]([OH:8])[CH:5]=[CH:4][CH:3]=1)[CH3:12]

参加物

3

反応物 2

HCID 15050Trimethyl orthoacetateHCID 1785076342-Amino-6-hydroxypyridine

生成物 1

HCID 178495861HCID 178495861、化合物

実験手順

4.4 g (40 mmol) of 6-amino-2-hydroxypyridine are heated under reflux for 12 hurs in 30 ml of orthoacetic acid trimethyl ester The reaction mixture is then concentrated by evaporation Ether is added to the residue while stirring, the product crystallising out spontaneously. The product is filtered off with suction and dried under a high vacuum. N-(2-hydroxy-6-pyridyl)-acetimidic acid methyl ester having a melting point of 128°-129° is thus obtained.

後処理

  1. concentrationis then concentrated by evaporation Ether
  2. additionis added to the residue
  3. customthe product crystallising out spontaneously
  4. filtrationThe product is filtered off with suction
  5. customdried under a high vacuum

出典と根拠

ORDレコード
ord-3be86dfd3d214280b3f286795a2c6ffe
出典データセット
uspto-grants-1989_09
特許番号
US04863938

反応ノート

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