Propylamine → HCID 178457528、化合物

HRID 1607086ノート

反応式

HRID 1607086 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([NH:8][CH:9]=[N:10][C:11]#N)[N:3]=1.[CH2:13](N)[CH2:14]C>O>[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([NH:8][CH:9]=[N:10][CH2:11][CH2:13][CH3:14])[N:3]=1

参加物

4

反応物 2

HCID 7852PropylamineHCID 178512261HCID 178512261、化合物

生成物 1

HCID 178457528HCID 178457528、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

2.3 g (14 mmol) of N-(2-hydroxy-6-pyridyl)-N'-cyanoformamidine are added in portions at room temperature over a period of 20 minutes to a stirred solution of 8.3 ml (99 mmol) of n-propylamine in 8 ml of water The reaction mixture is stirred for 2 hours at room temperature It is then extracted three times with chloroform The combined organic phases are dried over MgSO4 and concentrated by evaporation. The resulting crude product is chromatographed on silica gel with methylene chloride and then crystallised from ether/n-hexane. N-(2-pyridon-6-yl)-N'-propylformamidine and N-(2-hydroxy-6-pyridyl)-N'-propylformamidine having a melting point of 178°-179° are obtained.

後処理

  1. extractionis then extracted three times with chloroform The combined organic phases
  2. dry with materialare dried over MgSO4
  3. concentrationconcentrated by evaporation
  4. customThe resulting crude product is chromatographed on silica gel with methylene chloride
  5. customcrystallised from ether/n-hexane

出典と根拠

ORDレコード
ord-aad0c63e0b1e42f486e5574c2ef82aa0
出典データセット
uspto-grants-1989_09
特許番号
US04863938

反応ノート

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